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1996-02-27
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Document 0467
DOCN M9630467
TI High purity factor VIII concentrates for the treatment of HIV-positive
patients with haemophilia.
DT 9603
AU Sultan Y; Centre de l'Accueil et de Traitement des Hemophiles, Hopital;
Chochin, Paris, France.
SO Blood Coagul Fibrinolysis. 1995 Jul;6 Suppl 2:S80-1. Unique Identifier :
AIDSLINE MED/96076204
AB Some factor VIII concentrates cause downregulation of the immune system
in HIV-positive haemophilia patients. This effect appears to be related
to the purity of the concentrate, but not to its method of preparation.
The optimum purity for preventing downregulation is not known at
present.
DE Adolescence Adult Chromatography, Ion Exchange CD4 Lymphocyte Count
Down-Regulation (Physiology) Factor VIII/ADVERSE EFFECTS/*ISOLATION &
PURIF Hemophilia/*COMPLICATIONS Human HIV Seropositivity/*DRUG
THERAPY/IMMUNOLOGY Middle Age JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).